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The cause of brucellosis infection in Lanzhou Veterinary Research Institute is unknown, and there are many hidden dangers in the laboratory animal industry!

Published.

2023-02-23 13:20

The specifications have been issued, but the actual operation is far from being standardized. According to industry insiders, the quality control of domestically produced experimental animals is mainly controlled by the manufacturers themselves, and there is currently no compulsory uniform standard.

Wen | She Wen

Students are recessive and may affect employment

Lanzhou Institute of Veterinary Research has new cases of brucellosis.

Today (December 10), the website of the Heilongjiang Provincial Health and Health Committee announced that at 17:00 on December 7, 2019, the Heilongjiang Provincial Center for Disease Control and Prevention monitored 6 cases of brucellosis diagnosed by the Provincial Agricultural Reclamation General Hospital through the direct reporting system of infectious disease network , Are students of the School of Veterinary Medicine (Harbin Institute of Veterinary Medicine), Graduate School of the Chinese Academy of Agricultural Sciences. As of 17:00 on December 10, 13 people with Brucella antibody-positive reports related to the outbreak, including 1 confirmed case of brucellosis, 2 suspected cases, and 10 recessive infections.

An epidemiological survey showed that the 49 students who came to the clinic were from the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 37 of whom had short-term animal contact research work in the laboratory of the Lanzhou Veterinary Research Institute in August this year. Animal contact history, 13 cases were finally diagnosed. The other 12 students who had not worked in Lanzhou Animal Research Institute in August were not infected. Experts evaluated the outbreak as an imported one.

The earliest news of the incident came from the official website of the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences. The announcement describes that on November 28-29, the technical team of foot-and-mouth disease prevention and control of the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences reported that four students were serologically positive for brucellosis. After receiving the report, the Lanzhou Veterinary Research Institute immediately sent people to accompany the students to the hospital for treatment, and at the same time established an investigation team to close the related laboratories and conduct investigations. Up to now, a total of 263 people have been tested and 65 people have been serologically confirmed by the Gansu Provincial Center for Disease Control and Prevention. Some of the seropositive individuals felt physically uncomfortable, and the others did not show obvious clinical symptoms.

According to the "Plan for Establishing a Leading Group for Emergency Response to Suspected Brucella Infection" of the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences posted on campus, the first 4 students who were detected to be seropositive belong to the FMD prevention and control technical team, and the second The team that detected seropositivity was the Veterinary Nanomaterials and Applications Research Group.

According to CCTV reports, on the afternoon of December 7, the Lanzhou City Center for Disease Control and Prevention has tested Brucella for 317 teachers and students from the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (hereinafter referred to as the "Veterinary Research Institute"). Positive, all were recessive infections. At present, infected people have no typical symptoms and are still undergoing medical observation.

Blue Animal Research Laboratory Animal Center. Duan Yanchao Photography

Brucellosis (brothosis) is a zoonotic disease caused by Brucella that is negative and facultatively intracellular. It is usually transmitted to humans by diseased cattle, sheep, etc. There is almost no transmission from person to person. By 1886, the British medic Bruce had isolated Brucella from the spleen of a soldier who died of Malta fever on the island of Malta, and for the first time, the pathogen of the disease was identified and named Brucellosis. Brucellosis is an endemic disease in China, mainly distributed in Inner Mongolia, Northeast China, and Northwestern China. However, in recent years, a large number of brucellosis has also occurred in the South.

Although all students infected with brucellosis are recessive, some students are concerned that Brucella infection will affect future career development, because many infected students are majoring in veterinary medicine. Brucellosis testing. If the Brucella test is positive, you may encounter obstacles in finding a job.

Lanzhou Institute of Veterinary Medicine supplies experimental animals to various research institutions in Lanzhou

Lanzhou Institute of Veterinary Medicine was established in 1957, specializing in preventive veterinary research. The experimental animal center under it produces all kinds of mice, guinea pigs, experimental rabbits and other animals every year, and provides them to various scientific research institutions, colleges, universities, hospitals, medicine Factory etc. Brucellosis is generally transmitted through animal carcasses, hair, blood, etc., and is rarely transmitted from person to person. Lanzhou Institute of Veterinary Medicine is the source of experimental animals in many universities in Lanzhou. According to its official website, its experimental animal center produces 60,000 mice, guinea pigs, and 1,000 experimental rabbits each year. It is targeted at other scientific research and colleges. Schools, hospitals, and pharmaceutical factories provide experimental animals of different breeds, strains, and levels.

Out of concern for experimental animals of the Institute of Veterinary Medicine, since December 5th, medical students and animal medical students from various institutions in Lanzhou, including Lanzhou University, Gansu Agricultural University, and Lanzhou University of Technology, have begun in the Lanzhou Military Region. General Hospital Anning Branch (hereinafter referred to as "Lan Kong Hospital") and other hospitals performed Brucella testing. As of now, no other school students have been detected as seropositive.

Animal experiment management is not strict enough, occupational health care is not enough

The large-scale discovery of a recessive infection with Brucella started with the discovery of an experimental mouse infection. Several animal research institute students said that at the end of November, the foot-and-mouth disease control technology team found that the mice were infertile, and then examined the mice to find Brucella infection. Since then, cases of recessive brucella infection have appeared in students of different research groups.

No investigation results have been announced for the cause of the infection at Lanzhou Veterinary Research Institute. However, security loopholes must have occurred during the production of laboratory animals and the operation of animal experiments to cause the infection.

Professor Shao Qiming, general manager and chief scientist of Xi'an Guolian Quality Inspection Co., Ltd.'s Safety Evaluation Center, talked about the issue of occupational health management of experimental animal institutions in an interview with China Experimental Animal Information Network in March this year. She introduced that the domestic laboratory animal industry's overall attention to occupational health is not high, and the occupational health management system has not been implemented properly in the laboratory animal industry.

Professor Shao Qiming said, "Occupational hazards are distributed in many industries, and the incidence is increasing with social progress. International attention to occupational health is high. However, in China, overall attention to occupational health is not high. Occupational health issues Worry. In recent years, domestic attention to occupational health issues has increased, and the country has issued a series of laws, regulations and regulations. However, compared with other fields, the overall focus of the laboratory animal industry on occupational health is not high, and occupational health management The implementation of the system in the laboratory animal industry is not in place. Only a few units have established occupational health systems, and these units are mainly foreign companies. Many laboratory animal institutions lack professional occupational health management talents, and their employees pose occupational hazards. Reasons such as lack of awareness have not received due attention. How to establish an occupational health system in laboratory animal institutions is still an urgent issue. "

From the content of this interview, we can see that the domestic laboratory animal institutions have not paid enough attention to the occupational health of the practitioners, and many organizations' protective measures may be full of loopholes.

In addition to occupational protection, the standardization and standardization of domestic experimental animals and related institutions for animal experiments have just begun, and the standards for the quality of experimental animals and other standards have not yet been perfected.

In October of this year, China Experimental Animal Information Network interviewed Professor Tan Yi of the Experimental Animal Center of Chongqing Medical University. Professor Tan Yi is the main drafter of the national standard GB / T 35823-2018 General Requirements for Laboratory Animal Experiments.

Tan Yi introduced that the "General Requirements for Laboratory Animal Experiments" mainly regulates the animal experiment process of various institutions engaged in animal experiments, and specifically involves the following aspects:

1. Review of animal experiment protocols: This section specifies the duties, working principles, and working procedures of the Animal Management Committee (IACUC).

2. Management of animal laboratories: This section specifies the requirements for experimental animal management agencies, management personnel, management documents, quality assurance, and management of operational records. The level of management of animal experiments plays a key role in the standardized operation of animal experiments.

3. Experimental conditions: This section specifies the environmental facilities, feeding cages, equipment, feed nutrition, litter, drinking water, and safety protection of animal experiments. These contents affect the quality of animal experiments in addition to technical operations. Several hardware elements.

4. Quality of laboratory animals: The microorganisms, parasites, and genetics of standardized laboratory animals should meet the requirements of the corresponding GB and DB respectively; the use of animals that have not established corresponding national standards should meet the requirements of corresponding laws and regulations in order to maximize Limit the health of such animals. In short, the animals used for experiments should meet the requirements of relevant national standards, laws and regulations.

5. Basic technical operation specifications: This section specifies the requirements for laboratory animal acquisition, transportation, isolation and quarantine, Baoding, anesthesia and analgesia, postoperative care, benevolent endpoints, euthanasia and waste disposal. These contents run through the process of obtaining from experimental animals to execution. Good operating practices can effectively guarantee the quality of animal experiments and obtain scientific animal experimental data.

6. Experiment records and archives management: This section specifies the records and archives management of animal experiments. Animal experiment records and preservation play an important role in investigating animal experiment results and tracing animal experiment data.

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The new working meeting of the Professional Committee of Aquatic Laboratory Animals of the Chinese Society of Laboratory Animals was held in Nanjing

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The new working meeting of the Professional Committee of Aquatic Laboratory Animals of the Chinese Society of Laboratory Animals was held in Nanjing